We doubled human lifespans in the last 200 years. Can we do it again? | Andrew Steele
In the thought-provoking video “We doubled human lifespans in the last 200 years. Can we do it again?” Dr. Andrew Steele explores the transformative potential of longevity science. Rather than focusing on superficial measures to prolong life—like extreme diets or excessive supplements—Steele emphasizes the importance of improving our health span, the period of life spent free from diseases. He highlights that advancements in medicine have already doubled our life expectancy, and further slowing down the aging process could yield immense economic benefits, potentially saving $38 trillion.
Steele, a longevity scientist and author of “Ageless: The New Science of Getting Older Without Getting Old,” presents the stark reality of aging: our risk of death increases exponentially as we age. He introduces intriguing concepts like biological age versus chronological age and discusses groundbreaking techniques such as senolytic drugs and cellular reprogramming that may unlock the secret to healthier aging.
Amidst these exciting developments, Steele addresses the ethical questions surrounding longevity, arguing that advancements in this field should be viewed as an extension of modern medicine. As we stand on the brink of what could be a revolution in healthcare, Steele invites viewers to reconsider our understanding of aging and its implications on society.
Watch the video by Big Think
Author Video Description
“Over the last 10 or 15 years, scientists have really started to understand the fundamental underlying biology of the aging process. And they broke this down into 12 hallmarks of aging.”
Subscribe to Big Think on YouTube ► https://www.youtube.com/channel/UCvQECJukTDE2i6aCoMnS-Vg?sub_confirmation=1
Up next, Why 2025 is the single most pivotal year in our lifetime | Peter Leyden ► https://www.youtube.com/watch?v=w5k72A30kUc
We track age by the number of birthdays we’ve had, but scientists are arguing that our cells tell a different, more truthful story. Our biological age reveals how our bodies are actually aging, from our muscle strength to the condition of our DNA.
The gap between these two numbers may hold the key to treating aging – which could help save 100,000 lives per day and win us $38 trillion dollars.
00:00 Rethinking longevity
01:27 Understanding aging
02:58 Biological age and epigenetics
04:29 New frontiers in longevity science
08:04 Future possibilities and ethical questions
10:24 The moral debate around living longer
Read the video transcript ► https://bigthink.com/series/the-big-think-interview/aging-science-steele/?utm_source=youtube&utm_medium=video&utm_campaign=youtube_description
———————————————————————————-
Go Deeper with Big Think:
►Become a Big Think Youtube Member
Get exclusive classes and early, ad-free access to new releases without leaving Youtube. https://www.youtube.com/@bigthink/membership/
►Become a Big Think Web Member
Get the entire Big Think Class library, premium print issues, live events, and more.
►Subscribe to Big Think on Substack
Get all of your favorite Big Think content delivered to your inbox.
https://bigthinkmedia.substack.com/subscribe/ 
———————————————————————————-
About Andrew Steele:
Dr. Andrew Steele is a scientist, writer and campaigner based in Berlin, author of Ageless: The new science of getting older without getting old, and Director and Co-Founder of The Longevity Initiative.
About Big Think
Big Think is the leading source of expert-driven, actionable, educational content — with thousands of videos, featuring experts ranging from Bill Clinton to Bill Nye, we help you get smarter, faster. Get actionable lessons from the world’s greatest thinkers & doers. Our experts are either disrupting or leading their respective fields.
Video “We doubled human lifespans in the last 200 years. Can we do it again? | Andrew Steele” was uploaded on 11/03/2025 to Youtube Channel Big Think
					
							

































11:05 according to the chart, we can prevent 1,200,000 million deaths globally by driving safer.
I think it's sad that he's only talking about drugs, and how drugs will cure and prevent diseases. And even how we should dump exorbitant amounts of money in an AI that can design these drugs for us… While a change in lifestyle and diet is free and can accomplish much the same thing, right now, for everyone.
A) What the heck aspect is that video?
2) We doubled life-expectancy by vaccinating children, not extending the lifespan of old people.
iii) @7:15 — I would be excited about someone investing $3-billion in my research, too.
Why is your video so narrow?
We could make human life better and longer…. FOR CAPITALISM
How despicable have we become
yea well you didant
"we" maybe doubled the average life expectancy, but not the "human lifespan"
people living least 80+ years are known in history, which implies there also could be rare outliers living 100+
so where are our healthy retired 160+ old seniors living their active lives?
Sadly, most of these age related diseases are self-inflicted. Start with metabolic syndrome, then insulin resistance, pre-diabetic, diabetic, then all the prescription meds start. Diabetes medicine, statins, blood pressure medicines…. it's all downhill from there. Granted, the food industry and the big Pharma Industries have got us over a barrel, but if you pay attention you'll see what's really going on. Greed.
We owe it to ourselves to take control of our health.
I'm 62, do about 150 push-ups a day 6 days a week plus Pull-Ups. Started on June 1st with 6 push-ups. My opening set this morning was 50 and I hit 55 last week. I've been intermittent fasting for years and don't go to fast food places. Still 6 ft 32 waist, 175lbs, just like High School.
Plenty of supplements but absolutely no meds. Tested my A1C the other day 5.0. I'm not trying to live forever. I'm just trying to live the way I always have, for as long as possible. I still enjoy going and seeing rock bands which puts me on the road at 1:00 in the morning quite often. Intermittent fasting improved my vision years ago and I don't require any glasses. My ex had a similar experience where she was getting dizzy and thought she needed a new prescription after about 8 months of intermittent fasting and turned out she needed a weaker prescription not a stronger one.
I agree the age need special and skillful approach and science can be very useful in that job. Stanislaw Jerzy Lec once noticed: "Youth is the gift of nature, but age is a work of art". Anyway I think generally the purpose of research and experiments must not be longevity of the life but healthy and active life in old age.
its simple, natural selection. give some incentives for people to have children over 50.
In America, the current administration refuses to fund food, housing, and healthcare. It certainly won't invest in science that could lengthen our lives.
The average age at death may have been doubled, but the maximum age has barely changed. Without some "magic elixar"changing the nature of our cell's loss of telomeres, I suspect that we're not changing the aging paradigm.
I dont think we should, politicians dont need to lead is through multiple millenias
I don’t think aging is a disease cause not everybody gets to age and to age well it’s a honour and privilege at this point!!
human lifespan has already more than doubled from 35 yrs to over 75yrs …. aging is not a disease it is natural what is the point of living to 150yrs if you still have to work just to live . ..a longer life just equal more dept and cancer
no point in extending life span unless you can stop aging. people need to be fit enough to work to support themselves for 200 years!
Its not.
There are times when give thought I've looked younger & other people have also noticed it. Might have something to do with me sniffing poppers ?
Perhaps one of the most beautiful video I've ever seen in the while 🙂
highly skewed by infant mortality. If you made it to age 5, the average life expectancy was ~50 for this group. So I'd say we increased it 50% not 100%
I have to disagree. It's ALL about living forever. For him it might only be "a bit of longer living". For me it's LIVING FOREVER! Muhahaha!
The world needs mRNA.
Billionaires chasing immortality, so they can hold onto their wealth a little longer, suppose it means very little in the end
for the video editor: It's 2025. Ultra widescreen cinema aspect ratio was 2009 for faking ultra cinema as a film student. Now we do 4:3 again as hipster ratio 😉
The government doesn’t want you alive, they want you dead. You’re breathing up their air.
Haha, the title alone made me run. Live longer to keep the capitalist engine running 🙄
I hope not
I don't want us to be worth 38 trillion dollars, that just means we're getting exploited like four times as hard as we already are
People wasn't dying of old age at 29 years old in the 1800s… it's the average (quite low but lets play along) and they weren't dying of old age at 29 nor 39 also 10,000 years ago, that's clickbait
I think one piece of good news, is that evolution doesn't optimize heavily for longevity. If it did, it might be quite difficult to improve on it. The argument here is that most creatures in nature don't die of natural causes, they are either eaten or starve to death. A mouse that could live to be 20 years would never realize this increased life span because it would still die from predation or starvation within a couple years anyways. The signal for natural selection to work on, therefore, is very weak for ever increasing lifespan past the point of statistical death via other causes. There are exceptions that prove the rule. Bats are anatomically and metabolically quite like mice, but they actually live for 20 years. Why? because they can fly and escape predators more easily, reach a wider range of locations to find food, and roost safety where predators can't reach them. For bats, the selection pressures for increased lifespan are much stronger.
Humanity needs to stop using money as the driving force behind its goals.
Money has no true value — it’s merely a tool for exchanging it.
The real value lies in discovery and scientific advancement, which expand our collective knowledge and move humanity forward.
Where does that 38T number come from? I'm almost positive that's a hopium number that excluded the down sides. What I see is people living with their parents even longer, bad policy lasting even longer, people advancing at work takes longer….The compound interest problem is already destroying society. We don't need more resources to accumulate at the top.
Also, how is this number exactly the national debt? I'm sure it's just a coincidence…
Aerobic exercise training has been shown to have a positive effect on the decrease in senescent T cells circulating in the blood. This video raises an important question of how to expand this removal of senescent cells to all other tissues?
Sadly the area of reversing aging is massively underfunded according to ChatGPT. This should be the area where most of our investments should go. Let's contact billionaires to invest there. I want to live forever.
HI, it all comes from the fact that you are made of particles, and particles have existed from 13.5 Gyr , your particular arrangement tends to break as you age, is that arrangement that breaks appart, but if you could order particles in a particular manner you can LITERALY live forever is just engineering problem, just to mention, YES, humankind has atom level precision in the apparatus that you use right now
Reversing aging is massively underfunded. Sadly.
I would do this as long as I did not have to replace any organs. Another human's life is more valuable than an old man's.
babes how is this an interview?
This video is gorgeous! Definitely my new go-to when people ask me for an introduction to longevity science! Thanks so much for the interview. 🙂
If anyone has questions about longevity science or ethics, drop them in a comment below and I’ll get to as many as I can!