CRISPR Revolution: A Leap Forward in Live Animal Gene Editing
The CRISPR-Cas9 gene editing tool has been heralded as a monumental discovery in the field of molecular biology. This tiny but mighty tool has the potential to revolutionize medicine as we know it. Researchers from the University of California Berkeley have made significant progress in this area by developing a precision targeted delivery method for the CRISPR-Cas9 tool.
This innovative delivery method involves wrapping the editing proteins and guide RNAs in a membrane bubble adorned with monoclonal antibodies. These antibodies act as molecular homing devices, guiding the bubble to specific types of blood cells for precise editing. In a proof of principle study, researchers successfully targeted and edited T cells in live mice, transforming them into CAR T cells capable of eliminating other immune cells.
The ultimate goal is to streamline the process of manufacturing gene-edited CAR T cells to make them more widely available and affordable. The implications for human health are immense, with the potential for new treatments for diseases like cancer. Imagine a world where gene editing therapies are as common and accessible as a flu shot.
The CRISPR revolution in medicine is on the horizon, and it’s only a matter of time before it becomes a part of our everyday lives. Stay tuned for more updates on this groundbreaking technology.
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Video Transcript
Could you ever imagine that one day a tiny molecular tool could reshape our biology and potentially revolutionized medicine well that day might not be far off stick around to find out how this could change the course of disease treatment forever let’s start with the basics the chisar cast 9 Gene editing
Tool a discovery that’s been likened to the invention of the microscope holds the potential to rewrite the very fabric of Life as We Know It This tool allows us to modify our DNA the blueprint of life with an unprecedented level of precision recently researchers from the University of California Berkeley have
Made a significant Leap Forward in this field they’ve developed a Precision targeted delivery method for the crisper cast 9 tool taking us one step closer to unlocking its full potential here’s how it works the C 9 editing proteins and guide rnas the components that do the actual DNA cutting and and pasting are
Wrapped in a membrane bubble this bubble is decorated with monoclonal antibodies which are like molecular homing devices they guide the bubble to specific types of blood cells ensuring that only these cells are edited in a proof of principle study these researchers successfully targeted and edited te- cells in live
Mice the te- cells were transformed into car te- cells which are capable of eliminating another class of immune cells this is a major breakthrough as it could pave the way for new treatments for diseases like cancer but the researchers aren’t stopping there their aim is to streamline the process of
Manufacturing these Gene edited car T cells by delivering both the gene delivery and Gene knockout in specific cell types in Vivo or within the body they hope to make the process more efficient the ultimate goal to make crisper therapies more widely available and affordable today Gene editing
Therapies are expensive and limited to a few specialized medical centers but imagine a world where these therapies are as common and accessible as a flu shot the implications for human health are staggering so the question is not if but when this revolution in medicine will become a part of our everyday life
And before we end here’s the interesting tidbit we promised you earlier the name crispy R stands for clustered regularly interpace short palindromic repeats Now isn’t that a mouthful to continuously be enlightened like And subscribe
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The post “Advancing Live Animal Gene Editing in Science, DNA, Health, and Technology. – Video ” by GretAi was published on 03/27/2024 by news.gretai.com