How Suma Krishnan Built a Multibillion-Dollar Company at Age 51
In the world of biotechnology, few stories stand as inspiring as that of Suma Krishnan, a tenacious entrepreneur who defied conventional wisdom to create Krystal Biotech, a company now valued at $4.1 billion. Krishnan, a remarkable figure in the industry, founded the company at the age of 51, driven by a vision to tackle a rare yet devastating skin condition known as dystrophic epidermolysis bullosa (EB).
A Bold Beginning
Krishnan’s journey began with a personal connection to EB, a genetic disorder where the skin is so fragile it can tear and blister with minimal friction, much like the delicate wings of a butterfly. It was while reflecting on this harsh reality that she conceived the idea of a topical gene therapy. With her husband, Krish Krishnan, by her side, they decided to launch Krystal Biotech in Pittsburgh in 2016, choosing to steer clear of traditional venture capital funding.
The decision to remain independent was not without risks. “You have to be brave and bold to do this,” Krishnan emphasizes, embodying the spirit of entrepreneurship with her willingness to take chances. This resilience, alongside her refusal to conform to societal norms, has become a hallmark of her story.
Navigating the Challenges
Building a biopharma company from scratch comes with its own set of challenges, and for Krishnan, the road was anything but smooth. From navigating a daunting FDA approval process—especially complicated during the COVID-19 pandemic—to orchestrating a successful IPO that initially raised $50 million, the couple faced obstacles head-on. Their commitment yielded the first FDA-approved therapy for EB, a monumental achievement not only for the company but also for the patients who now see a glimmer of hope.
The Science Behind the Breakthrough
At the heart of Krystal Biotech’s success is its innovative approach to gene therapy. By utilizing a topical delivery system, the company’s treatment works at the molecular level to address the underlying causes of EB, transforming painful experiences into manageable ones for countless families. Krishnan’s vision extends beyond skin disorders; the science developed at Krystal is paving the way for potential applications in conditions like cystic fibrosis, showcasing a broader impact.
Personal Reflections and Advice
As her journey unfolds, Krishnan remains grounded, often drawing inspiration from the patients she serves. “What patients taught me about life is priceless,” she reflects, highlighting the poignant lessons learned through personal stories of struggle and resilience.
In her interactions with young women aspiring to carve their own paths in the business world, she offers sage advice: “Patience is your weapon.” This wisdom, tempered by her own experiences, empowers the next generation of leaders to embrace both their ambitions and the inevitable challenges they will face.
Conclusion
Suma Krishnan’s story is not just about building a successful company; it’s a testament to the power of courage, innovation, and tenacity. As she continues to impact lives through transformative therapies, her journey serves as an inspiration, proving that age is merely a number and that groundbreaking ideas can emerge at any stage of life. In a world where risk often feels daunting, Krishnan stands as a beacon, encouraging us all to dream big and act boldly.
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Video “How This Biotech Entrepreneur Built A Multibillion-Dollar Company At Age 51” was uploaded on 08/04/2025 to Dailymotion Channel Forbes